At present, there are two styles of scientific tests on itaconate: Irg1−/− macrophages along with the regulatory outcome of itaconate derivatives. These two results have been complementary and uncovered the regulatory mechanisms of itaconate involved alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription element three (ATF3) induction https://rowanszdim.timeblog.net/65586394/about-sr-18292