Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts within the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions... https://samueld824tbg7.wikimidpoint.com/user