Abstract Background Hi-C data have been widely used to reconstruct chromosomal three-dimensional (3D) structures. One of the key limitations of Hi-C is the unclear relationship between spatial distance and the number of Hi-C contacts. Many methods used a fixed parameter when converting the number of Hi-C contacts to wish distances. https://www.ngetikin.com/bargain-MLB-Texas-Rangers-Alternate-Away-Jersey-iPhone-14-Pro-Clear-Case-p111023-save-big/