Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Not like opioids, which bind to µ-opioid receptors in the central nervous system, conolidine modulates alternate molecular targets. A Science Advances study identified that conolidine interacts Along with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://beauxeghh.amoblog.com/about-alternative-natural-pain-relief-to-replace-traditional-painkillers-59478132